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AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis

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For instance, the production of lactic acid by tumours, CAFs and macrophages results in an immunosuppressive phenotype in macrophages, aiding tumour progression (Ruan and Kazlauskas, 2013)