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The overactivation of ACSL4, LPCAT3, and LOXs produces a large amount of phospholipid peroxides, which trigger ferroptosis

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For BSO group, a week later, mice received intraperitoneal administration of 750 mg/kg of body weight BSO (B113387, Aladdin) in phosphate-buffered saline (pH 7.4) once a day for two weeks 25

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Concurrently, non-oxidized dopamine lowered intracellular Fe 2+ accumulation by approximately 3040% at 25 M, decreased MDA production by about 2535% at 25 M, and sustained GSH levels restored by roughly 2030% compared with the erastin group