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10.1016/j.tcb.2015.12.002 Trends Cell Biol

Therefore, the proper maintenance of redox homeostasis can potentially serve as a rational therapeutic strategy to protect against OA progression

We underscore the need for future research to focus on advanced delivery systems and structural modifications, aiming to translate the promising in vitro findings of flavonoids into clinical and health applications

Once assembled, the NLRP3 complex triggers GSDMD-mediated pyroptosis, resulting in the release of pro-inflammatory cytokines and amplification of neuroinflammation [103,104,105,106] (Fig

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47 The NF-B member c-Rel is particularly important for mediating Treg development, and c-Rel acts by participating in the induction of Treg master transcription factor Foxp3