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How it works: Semaglutide mimics GLP-1, a naturally occurring incretin hormone that regulates blood sugar and appetite

CagriSema: GI adverse events reported by 79.6% (vs 39.9% placebo) in REDEFINE 1, mostly transient and mild to moderate

Gallbladder issues : Increased gallstone risk with rapid weight loss from GLP-1s

Pozzi V, Salvolini E, Lucarini G, Salvucci A, Campagna R, Rubini C, Sartini D, Emanuelli M (2020) Cancer stem cell enrichment is associated with enhancement of nicotinamide N-methyltransferase expression