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This evidence gap means clinicians must rely on mechanism-based reasoning rather than empirical DDI data

Additionally, numerous diseases are linked to oxidative stress-induced mtDNA damage (Lee and Wei, 1997

Arthritis & Rheumatism, 33(2), 160172

Chemotherapy-Induced Neuropathy Negative trial: A clinical study among people receiving platinum-based chemotherapy found that taking 600 mg of alpha-lipoic acid three times daily (1,800 mg total) for 24 weeks during chemotherapy did not reduce the incidence of chemotherapy-related nerve damage compared to placebo