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The onset and progression of cancer exploit gradual elevations in ROS levels

For example, peptides help orchestrate hormone activity, immune defense, tissue repair and growth, control of inflammation, and digestion

also acknowledge funding from Horizon Europe (PROTO-Advanced PeRsOnalized Therapies for Osteoarthritis-TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES, grant agreement ID: 101095635, and AM funding from ENgineered CArtilage from Nose for the Treatment of Osteoarthritis (ENCANTO), grant agreement ID: 101137315, A.M

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Overall, these data support a model whereby hemeHPX could potentially interact with a plasma membrane HSPG, possibly by binding ligands and then presenting them, as suggested for LRP1, for endocytosis (Kanekiyo et al., 2011)