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NRF2 glutarylation inhibits the binding of NRF2 to the E3 ubiquitin ligase KEAP1, reducing NRF2 ubiquitination and degradation, enhancing NRF2 stability, and DNA-binding activity [223]

SAS inhibits xCT and is used for the treatment of arthritis and inflammatory bowel disease, which can lead to ferroptosis, a potential cancer treatment method, as shown in Table 2

Many studies have also indicated the presence of oxidative stress in various types of human tumors compared to normal tissues [78,79,80], along with the alterations in the levels of antioxidant enzymes such as SOD in tumor tissues [81, 82]

PD patients often have low GSH levels in the substantia nigra

Numerous investigations have concentrated on the epigenetic regulatory mechanisms involved in ferroptosis, and the epigenetic regulators in ferroptosis include histone modifications, lymphocyte-specific helicase, long non-coding RNA, deubiquitinase, and selenium [46]

Clinical Pearl: Cyclobenzaprine is structurally a tricyclic compound