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MOTS-c is unusual because it comes from the DNA inside the mitochondria itself

Push the concentration up, especially past 1 to 10 micromolar in media that already holds serum, and the proliferation bump flattens or reverses

Eur J Pharmacol 613:146154 Wang C, Wang Q, Lou Y et al (2018) Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation