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These autoantibodies induce inflammation, vasoconstriction, and remodeling by directly binding to vascular cell targets, and activate the complement cascade and IgE-mast cell axis, amplifying pulmonary vascular inflammation and remodeling (Heukels et al., 2021

Glutathione peptide offers improved oral bioavailability compared to reduced glutathione, which degrades significantly in the digestive tract

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