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The ensuing mechanistic study revealed that ebselen protected cells and mice models by lowering radiation-induced ROS production, followed by inhibition of lipid peroxidation, protein carbonylation, DNA damage, and ultimately apoptosis

[44] [45] Although no specific PA susceptibility genes have been identified, a genetic factor likely is involved in the disease

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doi: 10.3892/ol.2014.2103 188 JungD-WCheZMKimJKimKKimK-YWilliamsDet al

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A dedicated cardiovascular outcomes trial (CVOT) for orforglipron has not been mandated by the FDA for initial approval but may be required or conducted voluntarily as a post-marketing commitment, following the precedent set by the SELECT trial for semaglutide