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-arrestin2: EC 50 = 3.9 0.003 M, NE EC 50 = 16.8 0.004 M) (Fig

In a study of 83 men with obesity, insulin resistance, and symptoms of low testosterone (including erectile dysfunction), those treated with tirzepatide for just two months saw significantly greater improvements than those receiving traditional testosterone replacement therapy (TRT) or lifestyle changes alone

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Because of semaglutide's 7-day half-life, these effects can last for days

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In contrast, melatonin levels were reduced in the tissues examined, particularly so in the brain