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The Phosphoinositide 3-Kinase (PI3K)/Akt pathway, while typically pro-survival, can be complexly modulated by pathological oxidative stress, impacting cardiomyocyte viability and metabolism in ways that may not always be protective (Lu et al., 2023)

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Similarly, another study identified that pancreatic cancer-associated fibroblasts (CAFs) can secrete acetic acid into the stroma of pancreatic cancer, which is mediated by ATP citrate lyase (ACLY)

2023 Nov 6;3(1):load041

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