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This results in: Systemic muscle growth across the entire body Enhanced fat metabolism and insulin sensitivity Ideal pairing with long-acting growth agents like HGH, MK-677, and anabolic steroids Long R3 IGF-1 was engineered to increase receptor activity and reduce IGFBP interference, extending its biological availability and enhancing systemic effects. Duan, Frontiers in Endocrinology IGF-1 DES (1-3): Targeted Anabolic Precision IGF-1 DES is a truncated analog that removes the first three amino acids from the IGF-1 protein chain