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In vascular smooth muscle cells (VSMCs), AC3, AC5, and AC6 are the most abundant isoforms in AR-mediated signaling, but during vasodilation, AC6 is the principal isoform involved in AR-mediated cAMP/PKA signaling and activation of the ATP-sensitive potassium current, thus playing an important role in setting the membrane potential

10.1111/bcp.12686 113 RussoA

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SLU-PP-332: Mice Lost 12% Body Weight in 30 Days DIO mice on SLU-PP-332 ran 70% longer and gained 10x less fat than controls