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The percentage is based on comparative animal studies measuring tensile strength recovery, histological organization, and macroscopic tissue closure at standardized post-injury time points

For longer-term laboratory storage, freezing at approximately 20C is commonly referenced in research settings to help maintain compound integrity

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Studies have explored growth hormone receptor upregulation and VEGF pathway activation as potential mechanisms that could explain this multi-tissue activity though the complete mechanistic picture remains an active area of investigation

Such studies indicated that synovial lining fibroblasts (Thy1-) were found to be predominantly responsible for driving articular damage, whereas sub-lining layer fibroblasts (Thy1 +) are mainly pro-inflammatory [30]