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The first reported methylation of p53 was lysine methylation by Set9 methyltransferase at K372, which positively stabilizes p53 by stabilizing the chromatin-bound portion of p53 ( 3.2.6 O-GlcNAcylation O-GlcNAcylation is another type of PTM, which involves the addition of N-acetylglucosamine (GlcNAc) to Ser or Thr residues (Figure 4D)

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A promising new approach to cancer therapy: targeting iron metabolism in cancer stem cells

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Mol Psychiatry 30 , 52155226 (2025)

In cell-based assays, ARA-290 is applied to cultured neuronal cell lines, primary Schwann cells, and pancreatic islet preparations to study receptor binding kinetics and intracellular signaling responses including STAT3 and NF-kB pathway modulation