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J Investig Dermatol Symp Proc , 7(1):2023

After 28 days, the benzyl alcohol concentration may be insufficient to prevent microbial contamination

Important considerations when utilizing the cuprizone model for preclinical therapeutic efficacy studies as part of drug development studies include determining the appropriate time window for both the intervention and the endpoint readouts

Factorial Approach Researchers have attempted to determine B12 needs by measuring daily B12 body losses, also known as the factorial approach

Mentink et al ., 2002), with the most prevalent type of non-enzymatic crosslinks being AGEs (see Table 2 for a summary on recent studies investigating AGE formation and impacts on tendon)