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In addition, fumaric acid may affect the catabolism of tyrosine and inhibit the enzyme activity therein, which ultimately leads to an elevation of tyrosine and so on in biochemical tests [85]

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For the E12.5 data, sample-specific relative quality weights were estimated using arrayWeights (Ritchie et al, 2006), and three surrogate variables computed by limmas wsva function were included to account for hidden confounders