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Moreover, cationic GS such as 12-312 have been reported to enhance gastrointestinal bioadhesion and improve the oral bioavailability of hydrophobic compounds, such as coenzyme Q10 nanocrystals, by promoting membrane interaction and improving solubilization [31]

doi: 10.1002/mnfr.202400048 86 FangJYuCHLiXJYaoJMFangZYYoonSHet al

The evolution of dichloroacetate (DCA) as a pharmaceutical agent has a more convoluted history (202)

doi: 10.1038/nm.4294 182 ZhongLLiuZZhouXSongSWengGWenYet al

This dynamic response suggested that NRN1 may act as a key switch in the transition from injury-induced suppression to repair initiation (Di Giovanni et al., 2005)

It has been shown that only D--OHB was able to inhibit glucose utilization in cardiomyocytes while L-stereoisomer had no effect (Tsai et al., 2006)