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Compared to sorafenib, sintilimab plus a bevacizumab biosimilar (Sint-IBI305) showed the greatest OS benefit (HR=0.57, 95% CI=0.430.75, P score=0.944), followed by camrelizumab plus rivoceranib (Cam-Rivo

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design factorial studies and confirm pathway engagement

Ketones are able to substitute glucose efficiently in mitochondria but they cannot substitute ATP generated in aerobic glycolysis

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