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[312] Consumption of coffee and tea, particularly 2-3 cups of coffee and more than 4 cups of tea per day, is associated with increased macular retinal nerve fiber layer (mRNFL) thickness, suggesting potential neuroprotective effects that warrant further investigation into causal links and mechanisms

More serious but less common risks include pancreatitis, gallbladder disease, acute kidney injury (often secondary to dehydration from gastrointestinal effects), and hypoglycaemia when used with insulin or sulphonylureas

Ans: Safety in pregnant or breeding pets has not been established

Vitamin B12 can help prevent premature greying

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and (ii) proliferative astrogliosis, which is anisomorphic with loss of domain, substantial structural reorganisation and can either be diffuse or can result in the formation of new compact limitans borders around overt fibrotic tissue lesions (Fig