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doi: 10.3389/fonc.2025.1613751 Received 17 April 2025 Accepted 29 September 2025 Published 24 October 2025 Volume 15 - 2025 Edited by Stefano Cairo, Champions Oncology, Inc., United States Reviewed by Janith Ananda Seneviratne, Peter MacCallum Cancer Centre, Australia Nevim Aygun, Ege University, Trkiye Updates Copyright 2025 Epp, Egan, Poon, Abdul Aziz, Wynne, Chesler, Halasz and Kolch

Nutritional inadequacies, enzyme defects, and pathological changes to tissues can all contribute to a reduced ability of the body to accomplish the synthesis of the active forms of vitamin B12 from CN-Cbl

Patients on the Perfect B Hair Quality Restoration program in Doral, FL who include GHK-Cu as part of their protocol often report noticeably denser, stronger hair by the end of the second cycle

Side effects from Vitamin B12 injections are rare and mild, such as minor redness or tenderness at the injection site

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