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Transient stress or increased cytoplasmic TDP-43 triggers phase separation into toxic cytoplasmic droplets that block nuclear import, deplete nuclear TDP-43, and cause cell death, offering a present mechanistic model for ALS/FTD pathology (Gasset-Rosa et al., 2019)

doi: 10.1016/j.neurobiolaging.2003.04.001 22 BretznerF.GilbertF.BaylisF.BrownstoneR

TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-B suppression

Lin J, Huang N, Li M, et al

Esophageal disorders including gastroesophageal reflux disease (GERD), esophagitis, and esophageal ulceration may benefit from BPC-157's demonstrated effects on esophageal sphincter function and mucosal healing in animal models

Randomized placebo-controlled trial of reloxaliase in enteric hyperoxaluria