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BMJ 2008;336(7644):6015

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Three patients had renal insufficiency as the likely cause for their anemia, with serum Cr values between 3.0 mg/dL and 5.4 mg/dL

These results collectively indicate that Sirt1 is indispensable for NNMT-mediated regulation of glucose metabolism, and both NNMT and MNAM have the ability to upregulate Sirt1 expression