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[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Kadry H., Noorani B., Cucullo L

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Because early symptoms are insidious, inflammation within the synovium and joint space often intensifies by the intermediate stage, and lesions extend into the cartilage, with extracellular matrix (ECM) degeneration, fibrosis within calcified cartilage, and chondrocyte hypertrophy (Mahmoudian et al., 2021)