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The downregulated metabolites were primarily associated with energy metabolism, including dephospho-CoA, AMP, ADP, oxidized glutathione, and NADP

Anti-adhesion therapy primarily utilizes monoclonal antibodies to inhibit 2-integrin function, thereby interfering with the adhesion and migration processes between leukocytes and endothelial cells (205)

In glutaminergic neurons, glutamine is catalyzed by glutaminase (GLS) to synthesize glutamate, which binds to certain receptors to form excitatory potential

Challenges and future perspectives in the clinical translation of PLGA nanoparticles for PD The previously discussed preclinical studies have shown the benefits of loading drugs and natural compounds into PLGA nanoparticles to enhance therapeutic efficacy, minimize systemic toxicity, and overcome peripheral side effects associated with PD medications