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The use of agents such as trientine and ammonium tetrathiomolybdate has been advocated, although results of long-term trials are awaited

The association between the genes of the -glutamyl cycle and autistic disorder is not well studied, although recently a relatively large study using a pathway approach showed a three-SNP joint interaction effect for glutaredoxin, glutaredoxin 3 and cystathione lyase (OR = 3.78, 95% CI: 2.36, 6.04) as well as marginal associations for cystathione lyase, the gamma-glutamylcysteine synthetase, catalytic subunit and glutaredoxin 3 suggesting that variation in genes involved in counterbalancing oxidative stress may contribute to autism [94]

Lynch WJ, Peterson AB, Sanchez V et al (2013) Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis