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The 4Rs is a general framework - this process needs to be personalized for each individual for the most targeted, effective, and well tolerated approach

doi: 10.3390/antiox13121504

Similarly, oral administration of steviol glycosides at doses up to 1,880 mg/kg for 4 weeks caused only mild increases in oxidative damage and chromosomal abnormalities in mice, whereas no genotoxic effects were observed at doses as high as 8,000 mg/kg in vivo (Orellana-Paucar, 2023)

1996 [cited 2025 Apr 2];73(2):20711

Vitamin A doses are measured in micrograms of retinol activity equivalents (mcg RAE)