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The resulting GSH deficiency renders GPX4 nonfunctional, allowing uncontrolled accumulation of lipid peroxides that disrupt membrane integrity and trigger ferroptotic cell death (Dixon et al

1112,1113 In Huntingtons disease, antisense oligonucleotides target mutant HTT mRNA to prevent disruptions in mitochondrial transport and function

Honokiol (HK), a biphenolic compound sourced from Magnolia bark, self-assembles into uniform spherical nanoparticles [68]