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The calcium-binding capacity of osteocalcin requires vitamin K-dependent -carboxylation of three glutamic acid residues

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That last area is interesting in that it also applies to GI damage done by NSAID overuse a very important field of research

[Google Scholar] Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation

A clinical diagnosis of drug-induced hepatic injury is easier to establish when the hepatotoxicity of the drug has been previously described and the associated clinical and pathologic features have been characterized (see discussion of specific drugs)