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And at the same time, we have to be realistic that we live in an unbelievably superficial image based culture

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Fatty acid synthesis consumes NADPH and generates NADP, serving as an electron sink and contributing to redox balance 318

The pentose phosphate pathway is the only source of NADPH in red blood cells, and the major function of NADPH in this cell type is to maintain the tripeptide glutathione (GSH) in its reduced state, which is needed to detoxify reactive oxygen species (Figure 3)

Even in individuals with a normal BMI, abdominal obesity was associated with a higher risk of oesophageal adenocarcinoma

But context matters: you lose muscle mass with any method of rapid weight loss