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Yet, their chemical synthesis remains as a long standing synthetic challenge for over six decades 5,6,7,8 , leaving various potential therapeutic targets inaccessible 3,6,7,9

Ipamorelin is a pentapeptide growth hormone secretagogue that acts through the ghrelin receptor (GHS-R1a) to stimulate growth hormone release

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109,146 (4) inhibits NLRP3, 147 a key inflammasome that activates pro-inflammatory cytokines, such as IL-1 and IL-18, which closely correlate with obesity and T2DM pathogenesis