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Nat Cancer 1 , 976989 (2020)

Cargo, PIP 2 , and Clathrin binding stabilize the open conformation

For example, nonobese diabetic (NOD) mice crossed with Keap1 knockdown mice ( NOD:Keap1 FA/ ) exhibited decreased pancreatic T-cell infiltration and increased insulin secretion compared with their NOD:Keap1 +/+ counterparts (83)