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The pro-inflammatory and pro-tumorigenic effect of TNF-, orchestrated by mutp53, results from the interaction between mutp53 and NF-kB

In this classical pathway, depletion of intracellular GSH and subsequent inactivation of GSH peroxidase 4 (GPX4) lead to the accumulation of lipid hydroperoxides, resulting in extensive membrane disruption and cell death (136)

As used herein, a subject is a mammal, preferably, a human

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Chan SSM, Luben R, et al

The treatment, administered at doses of 1.46, 2.92, and 5.84 mg/kg over 17 days, reduced AChE levels and increased ChAT levels, reversing scopolamine-induced cognitive deficits (Zhang et al., 2017a)