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Deficiency/sub-optimal cellular levels of Vitamin B12, via its metabolic effects through two key enzymes, creates a unifying cause of persistent pain, depression/anxiety and fatigue

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The molecular targets of various glutamate-modulating medications are shown in Figure 4

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Although enzymatic catalysis has been extensively explored in developing turn-on fluorescent probes, investigations into utilizing enzymatic reactions to regulate molecular aggregation states to realize more sophisticated and multifunctional biomedical applications remain rare 23,24,25

[DOI] [PubMed] [Google Scholar] 53.Williamson G, Clifford MN