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It has been shown that pathogenic bacteria or viruses in inflamed tissues promote ferroptosis in cells while activating immune cells and triggering inflammatory responses through the action of lipopolysaccharides, peptidoglycans, bacterial or viral DNA, and host cell toll-like receptors carried or released by themselves (60)

To examine the incorporation of GSH-derived cysteine into downstream pathways, we used an inverse stable-isotope labelling approach 34,35

The free radicals generated from these reactions can affect DNA, with substitutions of some DNA bases such as guanine with cytosine, guanine with thymine and cytosine with thymine (Jan et al., 2015)

We have excluded isolated and background nodes from this plot to focus on the relevant information

Table 1 Diverse sources and types of polyphenols, their antioxidant properties, and modes of action

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