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In summary, while glutamatergic excitotoxicity via NMDA receptors is a well-supported mechanism in tinnitus, the clinical application of broad antagonists has been limited

Getting the dose right is important, as injecting too much can cause unpleasant side effects

Mistaking this association for causation fuels unwarranted fear about vitamin B12 toxicity kidneys

Targeting CD36 pathways has emerged as a promising therapeutic strategy

Some researchers cycle the stack in 6-week on, 4-week off intervals to prevent adaptive downregulation of AMPK or NNMT pathways