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IGF-1 replacement therapy induced a restoration of the altered GH/IGF-1 axis by reducing circulating GH levels and recovering the somatostatinergic tone [292]

doi: 10.1016/j.bbrc.2018.07.100 113 WangRNGreenJWangZDengYQiaoMPeabodyMet al

Consequently, nanoformulations of antioxidant phytochemicals enhance these effects by overcoming the barriers of poor solubility, rapid metabolism, and limited bioavailability [266]