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Malignancies LCN2 exhibits highly context-dependent biological functions across various solid tumors and hematological malignancies, playing dual roles in tumorigenesis, metastasis, and therapy resistance via the regulation of ferroptosis

A recent 2022 study demonstrated that not only neurons but also glial cells rely on glutathione for homeostasis (12)

Dependence of mouse embryonic stem cells on threonine catabolism

Zeng Z, Baran N, Konoplev S, Cavazos A, Zhang Q, Kuruvilla VM, Lorenzi P, Kantarjian HM, Andreeff M , DiNardo CD, Murtie J, Ulanet D, Konopleva MY

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Only one RCT and five observational studies (14%) reported results for groups with VL 90%) reduction in the serum HBV DNA