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However, the development of AOD-9604 as an anti-obesity pill was terminated in 2007 for lack of effectiveness in trials [1]

These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane