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The key enzyme to determine the flux, positioned at the crossroad between upper and lower glycolysis, is GAPDH (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Kanner J

6 , 182195 (2012) R

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In contrast, our study confirmed decreased glutathione levels and increased ROS levels through BSO treatment or GCLC silencing, and revealed that while the depletion of glutathione did not compromise lymphoma cell survival in 2D culture, it sharply diminished viability in 3D gels