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The cells were cultured in DMEM/F-12 medium (11320033, Gibco, USA) supplemented with 5% horse serum and 2.5% fetal bovine serum at 37C under an atmosphere of 5% CO 2

As a D-amino acid peptide, FOXO4-DRI is costly to synthesize, and a wrong amino acid at the binding site can sharply cut activity

Tchang: Research-grade peptides are largely unregulated for human use in terms of sterility, purity and safety compared to FDA-approved peptides

Taken together, these results suggest that nuclear localization of FOXO4 may contribute to Leydig cell senescence and the downregulation of testosterone synthesis

\n Quick Answer Box: BPC-157 is a synthetic pentadic peptide derived from a protein found in gastric juice