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Results: Bid-/- Bim-/- Puma-/- Bcl-xL(-/-) Mcl-1(+/-) mice showed significantly lower levels of serum ALT and smaller number of TUNEL positive hepatocytes than Bid-/- Bim-/- Puma+/+ Bcl-xL(-/-) Mcl-1(+/-) mice

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One 1R6F cigarette was loaded into the magazine which loaded it into the cigarette holder port

In addition to the roles of lactate mentioned above, recent study has revealed that in myelofibrosis (MF), the abnormal accumulation of lactate can remodel the bone marrow microenvironment, driving the fibrotic progression of the disease by inducing an immunosuppressive state and promoting collagen deposition (Spampinato et al., 2025)