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Furthermore, recent research has uncovered that the gut microbiota regulates the metabolic reprogramming of alveolar macrophages through the NLRP6 inflammasome, enhancing neutrophil extracellular traps (NETs) and influencing bacterial clearance rates in the lungs (151, 152)

These systems enable precise drug release in tumor-specific pH environments while maintaining stability in normal tissue cells (Wike-Hooley et al., 1984