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mtDNA proximity to these ROS production sites makes them more vulnerable to damage, mutations, deletions, and genetic instability [16]

This type of invasion can compromise essential functions such as swallowing, speech, and breathing, making it crucial to balance tumor removal with functional preservation and quality of life

So far, there has been only one potential drug candidate for preventing the development of oxaliplatin-induced acute and delayed CIPN, namely, calmangafodipir, a mitochondrial manganese superoxide dismutase mimetic, which is currently being studied in a placebo-controlled, double-blinded randomized phase III study [24]

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201,206 Those populations are susceptible to SARS-CoV-2 infection, and timely immunization-enhanced measures should be performed to reduce breakthrough infections