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[PubMed: 16024919] 163

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This study was approved by the local Ethics Committee

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patented combination of 200 mg lidocaine alkalinized with sequential instillation of 8.4% sodium bicarbonate instilled once daily for 5 consecutive days with one hour retention), more patients in the treatment group (30% and 24% respectively) experienced clinically significant improvement compared to patients in the placebo group (10% and 11.5%, respectively)

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However, the trend of reduced stereotypic behavior on days 14 and 21 was observed in these combination groups as compared to their treatment alone (Fig

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It is not only the transition management approach that assumes that, following a systemic analysis of the initial situation, a long-term vision of wellbeing while respecting planetary boundaries is required in order to derive the necessary strategies and measures for the here and now (Loorbach 2010)

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The loss of function or alteration in reactive astrocytes not only affects the ion buffering system but also equally affects the neurotransmitter signaling cascade in the animal model of HD (Tong et al., 2014)

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