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CCM identifies nerve damage before symptoms or electrophysiological abnormalities appear [45, 46]

Vegetarians and vegans: Since most foods that contain B12 naturally are animal products like meat, eggs and dairy, vegetarians and vegans are at greater risk of developing a B12 deficiency

When intestinal flora dysbiosis occurs, metabolic disorders will occur, the permeability of the intestinal tract will increase and a large amount of intestinal bacterial metabolites, bacterial components and other harmful substances will enter the liver through the portal vein via the intestinal-hepatic axis and through the enterohepatic circulation reach the liver and bind to the TLR4 of hepatocytes and exacerbate the hepatic inflammatory response, oxidative stress and lipid accumulation, which further stimulate the inflammatory response

10.1016/j.carbpol.2016.12.068 45 LebeaupinC.ValleD.HazariY.HetzC.ChevetE.Bailly-MaitreB

Studies have shown that everyone with an autoimmune disorder, including Hashimotos thyroiditis, has some degree of intestinal permeability, or leaky gut