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The liver Phase II detoxification involves conjugation reactions, where toxins are linked to substances like glutathione to facilitate their excretion (60)

Whether subcutaneous AOD-9604 would have performed differently in a controlled trial remains an unanswered question

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Furthermore, tumor cell plasticity, including epithelial-mesenchymal transition (EMT), allows them to alter their phenotype to evade immune attack, and tumor heterogeneity creates distinct subpopulations, complicating treatment due to differential responses to therapy [180]

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I., de Martino, M., Lucca, I., Haitel, A., Shariat, S