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After remethylation, methionine can be reused to produce SAMe, the bodys universal methyl donor, which participates in several key metabolic pathways, including methylation of DNA and myelin, synthesis of carnitine, coenzyme Q 10 (CoQ 10 ), creatine, epinephrine, melatonin, methylcobalamin, and phosphatidylcholine (PC), as well as phase 2 methylation detoxification reactions

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KD used to treat refractory seizures in children was leading to the appearance of kidney stones 13,26

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An initial gradient of methanol: dichloromethane (0-25% over 10 min) was used, followed by a second gradient of chloroform:methanol:water (35:14:1, isocratic over 15 min)