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Crocodilian oil may also activate peroxisome proliferator-activated receptor gamma (PPAR- ), contributing to anti-inflammatory effects, improved cellular survival, and reduced neutrophil migrationactions believed to be PPAR- dependent (9)

Notably, the hippocampus, a region crucial for memory and learning, is particularly sensitive to these inflammatory insults, potentially linking systemic inflammation and BBB disruption to long-term cognitive deficits (Peng et al., 2019

Figures were generated using ChimeraX

[DOI] [PMC free article] [PubMed] [Google Scholar] Hamza AA

This review examines the relationship between energy metabolism and brain aging, highlighting the connection between MQC and energy metabolism, and proposes strategies to delay brain aging by targeting energy metabolism